Article Text

Download PDFPDF

The interaction of glucagon and pentagastrin on the lower oesophageal sphincter in man and dog
  1. H. M. Jennewein,
  2. F. Waldeck,
  3. R. Siewert,
  4. F. Weiser,
  5. R. Thimm


    The effect of glucagon on the pressure inside the lower oesophageal sphincter in conscious human subjects and anaesthetized dogs was investigated using the continuous withdrawal method. Glucagon causes a decrease in sphincteric resting pressure in both man and dog and antagonizes the pentagastrin-induced pressure increase of the lower oesophageal sphincter. In experiments on isolated muscle strips of the lower oesophageal sphincter of dogs glucagon decreases the tension and antagonizes the increase in tension induced by pentagastrin. The elevated pressure in patients suffering from achalasia is significantly reduced by glucagon.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.