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Effects on small-intestinal function and structure induced by feeding a deconjugated bile salt
  1. Michael Gracey,
  2. John Papadimitriou,
  3. Valerie Burke,
  4. Jennifer Thomas,
  5. Geoffrey Bower


    Feeding sodium deoxycholate orally to rats for three days caused inhibition of small-intestinal active sugar transport and ouabain-sensitive, sodium-potassium-dependent adenosine triphosphatase activity. At the same time, there was evidence of extensive ultrastructural damage to the microvillar and intracellular compartments of the small-intestinal epithelium while its light microscopic appearance was essentially normal. These functional and morphological changes reverted towards normal over the subsequent four days when a normal diet, without added bile salt, was reintroduced.

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