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Gluten-sensitive enteropathy: Synthesis of antigliadin antibody in vitro
  1. Z. Myron Falchuk,
  2. Warren Strober


    The intestinal mucosa of patients with gluten-sensitive enteropathy responds to gluten challenge in vivo with a striking increase in IgA and IgM synthesis. Whether this increase in immunoglobulin synthesis is due in some part to the production of antigliadin antibodies is examined. Using an affinity chromatography technique it has been demonstrated that in six of seven patients with gluten-sensitive enteropathy approximately half of the net increase in IgA and IgM synthesis occurring after gluten challenge can be attributed to the synthesis of antigliadin antibody. These data strengthen the hypothesis that immunological phenomena are related to the pathogenesis of glutensensitive enteropathy.

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    • 1 Presented in part at the national meeting of the American Federation for Clinical Research 2 May 1971, and at the Second Coeliac Symposium, Leyden, Holland, 11 March 1974.

      Portions of this work were carried out while Dr Falchuk was an Associate at the Digestive and Hereditary Diseases Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, Bethesda, Maryland.