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Immune response to phi X 174 in man. 5. Primary and secondary antibody production in primary biliary cirrhosis.
  1. H C Thomas,
  2. R Holden,
  3. J V Jones,
  4. D B Peacock


    In primary biliary cirrhosis, the primary immune response to the bacteriophage phi X 174 is normal but the secondary response is significantly reduced. The reduction is primarily of IgG antibody, while IgM is proportionately less affected. These changes may be the result of a reduction in helper T lymphocyte function and may contribute to the increase in the ratio of serum concentration of IgM to IgG.

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