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Research Article
Effect of histamine receptor antagonists on bile damage to the gastric mucosa of canine Heidenhain pouches.
  1. W D Rees,
  2. J Rhodes,
  3. M H Wheeler,
  4. E M Meek,
  5. B Williams,
  6. R G Newcombe

    Abstract

    The net ionic fluxes of H+ and Na+ were examined in Heidenhain pouches during damage with sodium taurocholate solution. The increase in ionic flux which occurred with taurocholate could be prevented in animals given H1 and H2 histamine antagonists in combination. The results suggest that histamine mediates changes in the transmucosal ionic flux produced by bile acid.

    https://doi.org/10.1136/gut.18.10.821

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