Article Text

Download PDFPDF
Bile acid studies in uncomplicated Crohn's disease.
  1. G Vantrappen,
  2. Y Ghoos,
  3. P Rutgeerts,
  4. J Janssens


    The pool size and composition of bile acids were studied in 13 unoperated patients with uncomplicated Crohn's disease; 10 patients with ulcerative colitis, and 10 normal subjects. Many patients with Crohn's disease had in their bile a significantly increased amount of ursodeoxycholic acid. The bile acid pool size was significantly decreased and the ratio of glycine to taurine conjugates was significantly increased in the Crohn's disease patients. The reduction in bile acid pool size was related to the activity of the disease. The disorders of bile acid metabolism suggest that the intestinal involvement in Crohn's disease is much more extensive than can be demonstrated by careful radiological examinations.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.