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Oral BCG vaccine in Crohn's disease.
  1. W R Burnham,
  2. J E Lennard-Jones,
  3. P Hecketsweiler,
  4. R Colin,
  5. Y Geffroy


    In a randomised double-blind trial over one year oral BCG has been compared with a control preparation in the treatment of chronic Crohn's disease. Overall assessment scores deteriorated in nine of 22 patients taking BCG, and 11 of 26 in the control group (P = 0.25); this deterioration was great enough to be regarded as a clinical relapse in three patients taking BCG and in seven taking the control preparation (P greater than 0.1). No significant benefit from oral BCG treatment has been demonstrated.

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