Article Text

Download PDFPDF

Platelet dynamics in chronic liver disease using the 111Indium oxine label.
  1. P J Toghill,
  2. S Green


    Platelet dynamics in chronic liver disease have been studied using 111Indium-8-hydroxyquinolone (111In-oxine) as a platelet label. In 20 patients, mainly with alcoholic cirrhosis, the platelet mean life span was reduced in 12 and the splenic platelet pool increased, often markedly so, in 15. However, the platelet count was not significantly related to mean bile span, the splenic platelet pool, or spleen size. Whereas splenic platelet pool size is related to spleen size in most of the haematological 'big-spleen' syndromes, this did not apply to those patients with chronic liver disease. Technically, 111In-oxine is a more appropriate platelet label than 51Cr in ill and thrombocytopenic patients with liver disease.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.