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Research Article
Penetration of albendazole sulphoxide into hydatid cysts.
  1. D L Morris,
  2. J B Chinnery,
  3. G Georgiou,
  4. G Stamatakis,
  5. B Golematis

    Abstract

    The penetration of albendazole sulphoxide, the principal metabolite of albendazole into hydatid cysts (E granulosus) was measured by means of in vitro animal and clinical studies. The drug freely diffuses across the parasitic membranes. Cyst/serum concentrations of 22% were achieved in patients, longer pre-operative therapy produced higher concentrations.

    https://doi.org/10.1136/gut.28.1.75

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