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Colonic bacterial proteases to IgA1 and sIgA in patients with ulcerative colitis.
  1. G D Barr,
  2. M J Hudson,
  3. J D Priddle,
  4. D P Jewell


    The colonic faecal and mucosal associated bacterial populations of five patients with ulcerative colitis and four control patients were studied in detail to assess their ability to produce IgA1-proteases. A total of 330 bacterial strains were isolated from the patients with ulcerative colitis and IgA1-protease activity was unable to be reliably shown in any. It is therefore unlikely that such enzyme production by colonic bacteria plays a significant role in the pathogenesis of ulcerative colitis.

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