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Histocompatibility antigens in patients with alcoholic liver disease in Scotland and northeastern England: failure to show an association.
  1. P R Mills,
  2. R N MacSween,
  3. H M Dick,
  4. W S Hislop
  1. Department of Medicine, Royal Infirmary, Glasgow, Scotland.


    A study of HLA-A and B antigens in 248 patients with biopsy diagnosed alcoholic liver disease was conducted to examine for a genetic predisposition to alcohol related liver injury. No statistically significant differences were established for 8 HLA-A and 16 HLA-B antigens between normal healthy controls (n = 342) and patients with alcoholic fatty liver (n = 86), alcoholic hepatitis (n = 63), active alcoholic cirrhosis (n = 64) and inactive alcoholic cirrhosis (n = 35). It is concluded that no HLA-A or B locus genetic susceptibility to alcoholic related injury could be shown.

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