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Dissolution of gall stones with an ursodeoxycholic acid menthol preparation: a controlled prospective double blind trial.
  1. M Leuschner,
  2. U Leuschner,
  3. D Lazarovici,
  4. W Kurtz,
  5. A Hellstern
  1. Zentrum der Inneren Medizin, Johann Wolfgang Goethe-Universität, Frankfurt/Main, Federal Republic of Germany.


    In a controlled prospective double blind trial patients with cholesterol gall bladder stones are treated with ursodeoxy-cholic acid (group A: UDCA 11.1 mg/kg per day; n = 16) and Ursomenth respectively (group B: a mixture of UDCA/menthol: 4.75 mg/kg per day each; n = 17). With same stone number and size (10-12 mm) there is a complete dissolution rate in group A of 38%, and of 53% in group B within 15-16.9 months. The response rate (complete + partial dissolution) amounted to 75% and 76% respectively. In group A there is one case of stone calcification, in group B none. Both preparations are free of unwanted effects. This suggests that the cyclic monoterpene menthol enhances the effect of UDCA and is of comparable effect to a mixture of six different terpenes used in former times.

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