Article Text

Download PDFPDF
Defective suppression in the autologous mixed lymphocyte reaction in patients with Crohn's disease.
  1. D Kelleher,
  2. A Murphy,
  3. C A Whelan,
  4. C Feighery,
  5. D G Weir,
  6. P W Keeling
  1. Department of Clinical Medicine, Trinity College Dublin, Medical School, St James' Hospital, Dublin.


    T helper and suppressor cell control of autologous immunoglobulin production was measured in 14 patients with Crohn's disease (CD) using autologous B cells or monocytes to stimulate regulatory T-cell activity. A pronounced defect in suppressor cell function was observed in the patient group but not in matched controls irrespective of whether B cells or monocytes were used as the stimulus. This defect was observed for IgG, A and M. This defect was seen both in patients with active disease and with inactive CD suggesting the possibility that a primary regulatory defect might exist in this disease. The patient group displayed normal helper cell function.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.