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Enhanced intestinal glucose and alanine transport in cystic fibrosis.
  1. P Baxter,
  2. J Goldhill,
  3. J Hardcastle,
  4. P T Hardcastle,
  5. C J Taylor
  1. Department of Biomedical Science, The University, Sheffield.


    The rise in short-circuit current associated with the active transport of glucose and alanine was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of an increased maximum rate of transport. Similar results were obtained with alanine. These findings suggest that active Na(+)-linked nutrient transport is enhanced in cystic fibrosis.

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