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Glutathione S-transferases in alcoholic liver disease.
  1. D J Harrison,
  2. L May,
  3. P C Hayes,
  4. M M Haque,
  5. J D Hayes
  1. Department of Pathology, University of Edinburgh.


    There is already evidence in alcoholic liver disease, mostly from studies of morphology and cytokeratin distribution, that hepatocytes can undergo a variety of phenotypic changes. This study reports findings of immunohistochemistry using antibodies against members of the glutathione S-transferase supergene family of detoxification enzymes. Hepatocytes in severe alcoholic liver disease coexpressed both alpha and pi class glutathione S-transferase. This coexpression has been previously described only in human fetal liver and in chemically-induced preneoplastic foci in rat liver. The use of function associated markers should provide additional information in the investigation of liver disease.

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