Article Text

Download PDFPDF

Effects of recombinant alpha interferon on chronic active hepatitis B: preliminary results.
  1. Y Bayraktar,
  2. B Uzunalimoglu,
  3. S Arslan,
  4. T Koseoglu,
  5. B Kayhan,
  6. H Telatar
  1. Hacettepe University Hospital, School of Medicine, Department of Gastroenterology, Ankara, Turkey.


    This paper presents the preliminary results of a study designed to evaluate the effects of alpha interferon in chronic hepatitis B. After six months' treatment with interferon alfa-2b (5 million units (MU), three times weekly) 15 of 25 (60%) patients achieved seroconversion of hepatitis B e antigen, 17 (68%) normalised alanine aminotransferase (ALT) activity, and 15 (60%) showed a decrease in the inflammatory reaction on liver histology. No seroconversions occurred in the control group (n = 10), and none of the control patients achieved a normal ALT or showed a reduction in the inflammatory reaction. Adverse effects were experienced by most patients who received interferon but none warranted stopping the treatment.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.