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Recombinant alpha interferon for chronic hepatitis B in anti-HIV positive patients receiving zidovudine.
  1. P Marcellin,
  2. N Boyer,
  3. J F Colin,
  4. M Martinot-Peignoux,
  5. V Lefort,
  6. S Matheron,
  7. S Erlinger,
  8. J P Benhamou
  1. Service d'Hépatologie, Hôpital Beaujon, Clichy, France.


    In this pilot study of the effects of interferon alfa in 10 anti-HIV positive, chronic hepatitis B patients treated with zidovudine (AZT), tolerance to interferon was good and similar to that in anti-HIV negative patients. After treatment, the HIV stage and CD4 lymphocyte count were unchanged. In two patients hepatitis B virus (HBV)-DNA and hepatitis B e antigen (HBeAg) disappeared and the serum alanine aminotransferase (ALT) returned to normal; loss of hepatitis B surface antigen (HBsAg) with absence of histopathological activity was observed after treatment in one of these patients. These preliminary results need to be confirmed by a larger study.

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