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Transforming growth factor beta 1: in situ expression in the liver of patients with chronic hepatitis C treated with alpha interferon.
  1. P Bedossa,
  2. T Poynard,
  3. P Mathurin,
  4. G Lemaigre,
  5. J C Chaput
  1. Laboratoire d'Anatomie Pathologique, Hôpital Antoine Beclere, Clamart, Paris, France.


    In a semiquantitative assessment of the expression of transforming growth factor (TGF) beta 1 in liver biopsy specimens from patients with chronic hepatitis C, treatment with interferon alfa-2b (3 million units (MU) three times weekly) decreased the expression of TGF beta 1 in six of seven patients. The reduction in TGF beta 1 correlated significantly with the scores for inflammation (p < 0.05) and necrosis (p < 0.05), but not with the alanine aminotransferase activities (p = 0.36) or the score for fibrosis (p = 0.86).

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