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Effect of Escherichia coli enterotoxins on macromolecular absorption.
  1. M Verma,
  2. S Majumdar,
  3. N K Ganguly,
  4. B N Walia
  1. Department of Paediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.


    Macromolecular absorption of gliadin, a wheat protein and alpha lactalbumin, a milk protein was evaluated in control and Escherichia coli enterotoxin (heat-stable, heat-labile, and both heat-stable and heat-labile enterotoxin) treated mice. The peak concentration of gliadin and lactalbumin was two hours and three hours after their ingestion, respectively. There was also a significant increase (p < 0.01) in the absorption of both the proteins in all the three toxin treated groups compared with the control group. These results suggest that intestinal permeability and macromolecular absorption changes after E coli infection.

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