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Analysis of Ha-ras 1 allele frequencies in hereditary non-polyposis colorectal cancer.
  1. P Jeevaratnam,
  2. P J Browett,
  3. N S Van de Water,
  4. J R Jass
  1. Department of Molecular Medicine and Pathology, School of Medicine, University of Auckland, New Zealand.


    Restriction enzyme digests of genomic DNA show multiple alleles of common, intermediate, and rare frequencies at the minisatellite locus of Ha-ras. It has been suggested that a higher frequency of rare alleles is associated with the presence of colorectal and other types of cancer. This study investigated the distribution of Ha-ras alleles in 40 members of hereditary non-polyposis colorectal carcinoma (HNPCC) families and in 34 cancer free subjects (spouses). There was no difference in rare allele frequency between the cancer group and cancer free group (chi2 = 0.25, not significant).

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