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Chronic intrahepatic cholestasis in sickle cell disease requiring exchange transfusion.
  1. A O'Callaghan,
  2. S G O'Brien,
  3. M Ninkovic,
  4. G P Butcher,
  5. C S Foster,
  6. J R Walters,
  7. I A Roberts
  1. Department of Haematology, Royal Postgraduate Medical School, London.


    A 15 year old boy with sickle cell disease developed intrahepatic cholestasis. A course of exchange transfusion successfully corrected the extreme hyperbilirubinaemia over one year. Upon stopping the exchange transfusion programme the hyperbilirubinaemia relapsed but transfusion was effective when reinstituted.

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