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Mesalazine induced exacerbation of ulcerative colitis.
  1. K C Kapur,
  2. G T Williams,
  3. M C Allison
  1. Department of Gastroenterology, Royal Gwent Hospital, Newport.


    5-Aminosalicylic acid (5-ASA) compounds occasionally exacerbate diarrhoea in patients with inflammatory bowel disease. This is thought to be due to a secretory mechanism in most cases. A patient with presumed intolerance to sulphasalazine and 5-ASA preparations who developed endoscopic and histological evidence of disease relapse after a rectal challenge with mesalazine is reported.

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