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A case of Churg-Strauss syndrome: tissue diagnosis established by sigmoidoscopic rectal biopsy.
  1. E J Leen,
  2. P J Rees,
  3. J D Sanderson,
  4. M L Wilkinson,
  5. M I Filipe
  1. Department of Histopathology, Guy's Hospital, London.


    A case is presented of Churg-Strauss syndrome in a young man in whom the definitive diagnostic procedure was a full thickness sigmoidoscopic rectal biopsy, with submucosal sampling. Gastrointestinal changes in Churg-Strauss syndrome, a rare systemic illness characterised by asthma, blood and tissue eosinophilia, vasculitis, and granulomatous inflammation are common but poorly reported. The endoscopic and histopathological features of a case are described and emphasise the potential value of a limited sigmoidoscopy in establishing the diagnosis, when lower gastrointestinal symptoms are present.

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