Article Text
Abstract
BACKGROUND The importance of host factors in helicobacter induced gastritis has been shown in animal models. Infection of most mouse strains withHelicobacter felis results in a functional atrophic gastritis, while other strains remain gastritis free.
AIMS To investigate these host factors further by using genetic crosses of responder and non-responder mice.
METHODS F1 hybrids of the non-responder CBA/Ca strain and three strains of mice known to develop H felis induced gastritis were infected for three months with H felis. Gastritis was assessed by histopathology and serum antibody responses by ELISA.
RESULTS Infection of CBA/Ca mice and F1 hybrids induced little or no gastritis. Analyses of the antibody responses in these mice revealed virtually undetectable anti-helicobacter antibody levels despite colonisation with high numbers of H felis. In contrast, infection of H felis responsive strains induced gastritis and a significant humoral immune response.
CONCLUSIONS The non-responsiveness of CBA/Ca mice to H felis infection is dominantly inherited. The lack of gastritis in CBA mice and their offspring is probably due to active suppression of the immune response normally mounted against H felis. Investigation of these mechanisms will provide important insights relevant to induction of gastric atrophy and cancer in humans.
- helicobacter
- non-responsiveness
- gastritis
- F1 hybrid
- CBA
Abbreviations used in this paper
- LPS
- lipopolysaccharide
- MHC
- major histocompatibility complex
- BHI
- brain heart infusion
Statistics from Altmetric.com
Abbreviations used in this paper
- LPS
- lipopolysaccharide
- MHC
- major histocompatibility complex
- BHI
- brain heart infusion
Linked Articles
- Commentary