You are here

Article Text

Article menu
Download PDFPDF
Helicobacter pylori
Effects of Helicobacter pylorieradication on the natural history of lymphocytic gastritis
  1. M Hayata,
  2. D S Arorab,
  3. M F Dixonb,
  4. B Clarkc,
  5. S O’Mahonya
  1. aCentre for Digestive Diseases, The General Infirmary at Leeds, Leeds, UK, bAcademic Unit of Pathological Sciences, University of Leeds, Leeds, UK, cCellular and Molecular Immunology Laboratory at St James’s University Hospital NHS Trust, Leeds, UK
  1. Dr M Hayat, Gastroenterology Unit, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX, UK.

Abstract

BACKGROUND Lymphocytic gastritis is characterised by an accumulation of lymphocytes in the surface epithelium of the stomach. Lymphocytic gastritis has been linked to coeliac disease and Helicobacter pyloriinfection.

AIMS To determine whetherH pylori eradication leads to resolution of the lymphocytic infiltrate and clinical improvement in patients with lymphocytic gastritis, and to determine their HLA status.

METHODS The Leeds Dyspepsia Questionnaire (LDQ) was administered to 13 patients with lymphocytic gastritis. H pylori serology,13C urea breath test (UBT), and upper gastrointestinal endoscopy with sampling of the duodenum, antrum, and corpus were done in all cases and the HLA status was determined. Eleven patients had at least one positive test for H pylori. Patients with lymphocytic gastritis and H pylori infection were treated with a one week course of omeprazole, clarithromycin, and metronidazole. Gastric and duodenal intraepithelial lymphocyte (IEL) counts were performed, along with histological assessment of gastric and duodenal biopsies before and after H pylori eradication.

RESULTS Two months after treatment there was a significant reduction in gastric IEL counts in both antrum and corpus. There was no significant change in duodenal IEL counts before and after eradication. According to the Sydney grading there was significant improvement in corpus inflammation after eradication. The patients histologically H pylori positive before treatment became H pylori negative. Dyspepsia scores also improved significantly after treatment.

CONCLUSIONS H pylori eradication treatment in patients with lymphocytic gastritis causes significant improvement in the gastric IEL infiltrate, corpus inflammation, and dyspeptic symptoms. H pylori serology is frequently positive when histology and UBT are negative. Lymphocytic gastritis may represent a specific immune response to H pylori infection.

  • lymphocytic gastritis
  • intraepithelial lymphocytes
  • Helicobacter pylori
  • HLA status
  • coeliac disease

  • Abbreviations used in this paper

    IEL
    intraepithelial lymphocyte
    PBMC
    peripheral blood mononuclear cell
    UBT
    urea breath test

    • https://doi.org/10.1136/gut.45.4.495

    Statistics from Altmetric.com

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    • Abbreviations used in this paper

      IEL
      intraepithelial lymphocyte
      PBMC
      peripheral blood mononuclear cell
      UBT
      urea breath test
      • View Full Text