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MCP-3 in inflammatory bowel disease
  1. U HELWIG,
  2. K M LAMMERS,
  3. P GIONCHETTI,
  4. F RIZZELLO,
  5. M CAMPIERI
  1. M UGUCCIONI
  1. Department of Internal Medicine and Gastroenterology
  2. University of Bologna, Bologna, Italy
  3. Email: paolo@meol.unibo.it
  4. Theodor Kocher Institute
  5. University of Bern, Bern, Switzerland

https://doi.org/10.1136/gut.47.1.155

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    Editor,—We read with interest the article by Wedemeyer and colleagues (Gut1999; 44:629–35) on chemokines in inflammatory bowel disease.

    Monocyte chemotactic protein 3 (MCP-3) expression in inflammatory bowel diseases is a very interesting observation and we agree with the authors that MCP-3 might play an important role in the pathophysiology of these diseases.

    We have recently published an article on the C-X-C chemokines interleukin (IL)-8 and IP-10, and the C-C chemokines MCP-1 and MCP-3 in the mucosa of active ulcerative colitis.1 It concerns an immunohistochemical study in which we showed increased expression of these chemokines in the lamina propria of patients with ulcerative colitis compared with normal controls. Furthermore, we observed a significant difference in expression between inactive and moderate/severe ulcerative colitis …

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