Autoantibodies against the specific epitope of human tropomyosin(s) detected by a peptide based enzyme immunoassay in sera of patients with ulcerative colitis show antibody dependent cell mediated cytotoxicity against HLA-DPw9 transfected L cells

S Sakamaki; N Takayanagi; N Yoshizaki; S Hayashi; T Takayama; J Kato; K Kogawa; N Yamauchi; N Takemoto; A Nobuoka; T Ayabe; Y Kohgo; Y Niitsu

doi:10.1136/gut.47.2.236

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Inflammatory bowel disease

Autoantibodies against the specific epitope of human tropomyosin(s) detected by a peptide based enzyme immunoassay in sera of patients with ulcerative colitis show antibody dependent cell mediated cytotoxicity against HLA-DPw9 transfected L cells

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	Abstract	Full	Pdf
Jul 2000	24	26	19
Aug 2000	20	47	22
Sep 2000	13	19	7
Oct 2000	5	10	5
Nov 2000	1	4	3
Dec 2000	1	14	10
Jan 2001	40	5	3
Feb 2001	4	8	2
Mar 2001	1	4	5
Apr 2001	7	10	11
May 2001	2	9	5
Jun 2001	0	3	3
Jul 2001	1	11	10
Aug 2001	2	6	1
Sep 2001	1	6	1
Oct 2001	3	5	2
Nov 2001	4	5	1
Dec 2001	1	2	2
Jan 2002	0	1	1
Feb 2002	0	1	0
Mar 2002	2	4	0
Apr 2002	3	8	3
May 2002	1	0	0
Jun 2002	1	2	3
Jul 2002	3	2	0
Aug 2002	1	3	0
Sep 2002	1	9	0
Oct 2002	3	3	0
Nov 2002	2	2	1
Dec 2002	4	0	0
Jan 2003	4	6	4
Feb 2003	2	3	2
Mar 2003	4	4	0
Apr 2003	2	1	2
May 2003	3	3	0
Jun 2003	2	3	0
Jul 2003	11	20	1
Aug 2003	20	14	0
Sep 2003	12	11	4
Oct 2003	16	42	6
Nov 2003	9	5	4
Dec 2003	16	11	4
Jan 2004	18	7	0
Feb 2004	10	9	0
Mar 2004	17	6	1
Apr 2004	17	10	3
May 2004	43	36	6
Jun 2004	54	46	8
Jul 2004	52	52	6
Aug 2004	26	30	10
Sep 2004	22	45	8
Oct 2004	9	30	3
Nov 2004	8	29	14
Dec 2004	5	18	8
Jan 2005	19	41	16
Feb 2005	6	13	7
Mar 2005	13	24	4
Apr 2005	8	9	5
May 2005	9	30	4
Jun 2005	1	15	4
Jul 2005	5	10	4
Aug 2005	6	17	10
Sep 2005	4	19	4
Oct 2005	5	17	2
Nov 2005	10	20	7
Dec 2005	5	17	6
Jan 2006	5	26	5
Feb 2006	4	18	4
Mar 2006	1	26	6
Apr 2006	4	25	1
May 2006	6	17	1
Jun 2006	1	11	5
Jul 2006	2	21	5
Aug 2006	2	11	3
Sep 2006	0	13	4
Oct 2006	3	32	5
Nov 2006	1	25	7
Dec 2006	7	14	3
Jan 2007	5	13	3
Feb 2007	1	12	4
Mar 2007	7	12	7
Apr 2007	2	7	3
May 2007	7	3	5
Jun 2007	7	6	4
Jul 2007	7	6	2
Aug 2007	4	0	0
Sep 2007	3	2	1
Oct 2007	4	2	1
Nov 2007	5	0	0
Dec 2007	3	3	1
Jan 2008	3	1	0
Feb 2008	1	4	1
Mar 2008	3	9	4
Apr 2008	4	2	3
May 2008	4	0	1
Jun 2008	11	0	1
Jul 2008	4	2	1
Aug 2008	27	1	1
Sep 2008	20	1	3
Oct 2008	14	2	2
Nov 2008	9	0	0
Dec 2008	13	1	1
Jan 2009	15	5	1
Feb 2009	5	0	0
Mar 2009	8	3	2
Apr 2009	4	2	0
May 2009	9	4	3
Jun 2009	10	1	0
Jul 2009	8	3	0
Aug 2009	2	0	0
Sep 2009	5	1	0
Oct 2009	7	2	0
Nov 2009	6	1	0
Dec 2009	5	0	0
Jan 2010	0	0	1
Feb 2010	3	0	0
Mar 2010	5	1	0
Apr 2010	5	2	0
May 2010	5	0	3
Jun 2010	12	1	2
Jul 2010	4	2	5
Aug 2010	4	1	0
Sep 2010	1	1	0
Oct 2010	18	1	0
Nov 2010	20	4	1
Dec 2010	11	6	0
Jan 2011	12	2	2
Feb 2011	8	6	3
Mar 2011	14	0	1
Apr 2011	6	4	1
May 2011	3	2	0
Jun 2011	4	2	1
Jul 2011	5	2	0
Aug 2011	13	0	0
Sep 2011	9	1	1
Oct 2011	10	1	0
Nov 2011	13	5	3
Dec 2011	11	4	6
Jan 2012	12	12	1
Feb 2012	16	12	2
Mar 2012	12	7	4
Apr 2012	13	3	8
May 2012	12	6	9
Jun 2012	11	11	7
Jul 2012	5	12	6
Aug 2012	13	7	8
Sep 2012	7	5	7
Oct 2012	23	8	6
Nov 2012	12	12	2
Dec 2012	14	5	5
Jan 2013	14	14	3
Feb 2013	12	6	5
Mar 2013	8	7	4
Apr 2013	7	7	5
May 2013	9	5	5
Jun 2013	5	4	1
Jul 2013	4	2	1
Aug 2013	16	2	4
Sep 2013	14	3	5
Oct 2013	9	5	7
Nov 2013	6	6	8
Dec 2013	13	7	9
Jan 2014	13	1	4
Feb 2014	1	3	3
Mar 2014	11	3	3
Apr 2014	11	2	6
May 2014	9	4	2
Jun 2014	17	3	1
Jul 2014	14	8	1
Aug 2014	4	7	6
Sep 2014	11	2	1
Oct 2014	16	23	0
Nov 2014	5	2	3
Dec 2014	2	1	1
Jan 2015	3	3	0
Feb 2015	8	4	4
Mar 2015	15	13	3
Apr 2015	0	10	1
May 2015	2	4	0
Jun 2015	2	1	2
Jul 2015	1	3	1
Aug 2015	10	2	2
Sep 2015	15	3	1
Oct 2015	4	0	1
Nov 2015	1	3	1
Dec 2015	8	1	2
Jan 2016	6	4	4
Feb 2016	5	3	2
Mar 2016	4	2	7
Apr 2016	14	9	11
May 2016	5	5	2
Jun 2016	8	5	0
Jul 2016	6	8	6
Aug 2016	7	4	0
Sep 2016	5	5	2
Oct 2016	10	1	3
Nov 2016	11	8	1
Dec 2016	11	5	0
Jan 2017	12	3	4
Feb 2017	2	6	0
Mar 2017	0	8	1
Apr 2017	1	7	0
May 2017	1	14	1
Jun 2017	0	3	1
Jul 2017	5	5	1
Aug 2017	12	12	2
Sep 2017	11	9	3
Oct 2017	13	13	2
Nov 2017	23	23	3
Dec 2017	8	6	1
Jan 2018	14	14	0
Feb 2018	18	19	3
Mar 2018	14	14	0
Apr 2018	12	12	0
May 2018	20	20	0
Jun 2018	19	19	0
Jul 2018	5	5	0
Aug 2018	6	6	0
Sep 2018	14	8	0
Oct 2018	11	9	1
Nov 2018	18	18	1
Dec 2018	15	15	2
Jan 2019	24	21	3
Feb 2019	34	30	6
Mar 2019	19	19	7
Apr 2019	13	13	6
May 2019	25	25	9
Jun 2019	27	25	3
Jul 2019	20	20	4
Aug 2019	6	6	6
Sep 2019	13	13	3
Oct 2019	30	30	1
Nov 2019	27	26	1
Dec 2019	37	37	6
Jan 2020	27	26	2
Feb 2020	16	16	3
Mar 2020	21	21	2
Apr 2020	15	15	2
May 2020	16	15	2
Jun 2020	33	33	6
Jul 2020	33	33	5
Aug 2020	22	22	3
Sep 2020	44	41	2
Oct 2020	24	24	2
Nov 2020	31	29	2
Dec 2020	37	37	5
Jan 2021	35	34	8
Feb 2021	12	12	3
Mar 2021	21	21	1
Apr 2021	25	25	4
May 2021	29	28	4
Jun 2021	34	33	5
Jul 2021	8	8	3
Aug 2021	4	4	5
Sep 2021	13	13	9
Oct 2021	8	6	26
Nov 2021	10	10	12
Dec 2021	12	12	3
Jan 2022	11	11	3
Feb 2022	10	10	0
Mar 2022	21	21	5
Apr 2022	12	10	7
May 2022	17	17	11
Jun 2022	25	25	5
Jul 2022	19	14	3
Aug 2022	25	24	3
Sep 2022	28	28	9
Oct 2022	33	32	6
Nov 2022	17	13	2
Dec 2022	11	9	2
Jan 2023	9	9	4
Feb 2023	31	31	0
Mar 2023	7	7	3
Apr 2023	7	7	6
May 2023	15	11	14
Jun 2023	4	2	2
Jul 2023	12	10	6
Aug 2023	11	11	5
Sep 2023	4	4	3
Oct 2023	19	17	3
Nov 2023	8	8	0
Dec 2023	39	4	0
Jan 2024	12	2	1
Feb 2024	40	2	0
Mar 2024	114	2	0
Total	3270	3025	933

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