Article Text

Download PDFPDF

Proton Pump Inhibitors

    Statistics from

    Proton Pump Inhibitors. Edited by Olbe L. (Pp 264; illustrated; sFr198.00.) Switzerland: Birkhäuser Verlag. 1999. ISBN 3 76435 897 1.

    The history of the development of drugs to treat the so-called acid related diseases makes a fascinating story, and the publication of this book addresses a significant chapter in that story. Before 1976, treatment of peptic ulcer and gastroesophageal reflux disease was either inadequate medical therapy involving antacids, non-selective anticholinergic drugs, or surgery with its associated morbidity problems. The advent of cimetidine (Tagamet), the first of the histamine H2 receptor antagonists revolutionised the therapy of these diseases, and cimetidine became the first billion dollar drug. Subsequently, ranitidine (Zantac) superseded cimetidine as the world's most successful drug.

    Despite their success, H2 antagonists had some limitations, particularly in the treatment of gastroesphageal reflux disease and the arrival of omeprazole, the first proton …

    View Full Text

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.