Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease

J-P Segain; D Raingeard de la Blétière; A Bourreille; V Leray; N Gervois; C Rosales; L Ferrier; C Bonnet; H M Blottière; J-P Galmiche

doi:10.1136/gut.47.3.397

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Inflammatory bowel disease

Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease

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	Abstract	Full	Pdf
Aug 2000	83	143	88
Sep 2000	67	130	85
Oct 2000	12	48	31
Nov 2000	9	56	26
Dec 2000	8	60	45
Jan 2001	5	53	80
Feb 2001	2	58	28
Mar 2001	7	36	27
Apr 2001	6	31	15
May 2001	4	35	20
Jun 2001	5	38	11
Jul 2001	4	51	8
Aug 2001	4	26	16
Sep 2001	0	24	11
Oct 2001	4	34	13
Nov 2001	4	53	43
Dec 2001	1	34	8
Jan 2002	4	21	7
Feb 2002	1	29	7
Mar 2002	5	48	22
Apr 2002	4	41	14
May 2002	4	26	11
Jun 2002	2	45	15
Jul 2002	1	24	7
Aug 2002	1	23	8
Sep 2002	2	25	7
Oct 2002	4	27	11
Nov 2002	4	31	12
Dec 2002	4	15	8
Jan 2003	4	17	8
Feb 2003	1	27	15
Mar 2003	2	21	9
Apr 2003	5	36	4
May 2003	7	18	7
Jun 2003	5	24	9
Jul 2003	11	37	10
Aug 2003	16	22	16
Sep 2003	21	23	3
Oct 2003	21	37	10
Nov 2003	24	25	11
Dec 2003	27	23	10
Jan 2004	29	23	10
Feb 2004	17	42	17
Mar 2004	27	44	16
Apr 2004	23	22	8
May 2004	50	74	21
Jun 2004	52	76	20
Jul 2004	49	68	19
Aug 2004	45	73	25
Sep 2004	34	68	22
Oct 2004	16	63	35
Nov 2004	18	52	36
Dec 2004	14	28	27
Jan 2005	18	56	20
Feb 2005	16	28	18
Mar 2005	24	43	23
Apr 2005	15	36	30
May 2005	10	32	18
Jun 2005	17	33	23
Jul 2005	12	36	20
Aug 2005	17	47	23
Sep 2005	18	34	20
Oct 2005	22	61	23
Nov 2005	20	45	29
Dec 2005	14	46	41
Jan 2006	14	42	28
Feb 2006	7	28	30
Mar 2006	9	43	57
Apr 2006	12	33	24
May 2006	18	25	30
Jun 2006	10	32	22
Jul 2006	24	36	27
Aug 2006	12	37	24
Sep 2006	11	53	24
Oct 2006	15	42	22
Nov 2006	20	51	35
Dec 2006	18	38	20
Jan 2007	15	30	24
Feb 2007	18	31	21
Mar 2007	25	61	23
Apr 2007	20	8	10
May 2007	19	11	10
Jun 2007	21	11	11
Jul 2007	14	19	9
Aug 2007	14	12	21
Sep 2007	17	14	7
Oct 2007	15	14	8
Nov 2007	13	16	23
Dec 2007	75	4	6
Jan 2008	38	11	10
Feb 2008	11	12	12
Mar 2008	25	15	12
Apr 2008	15	9	7
May 2008	18	9	7
Jun 2008	16	7	7
Jul 2008	25	7	10
Aug 2008	64	11	9
Sep 2008	40	9	15
Oct 2008	35	11	9
Nov 2008	47	14	14
Dec 2008	19	10	10
Jan 2009	14	8	5
Feb 2009	27	10	8
Mar 2009	31	7	6
Apr 2009	22	13	9
May 2009	18	10	5
Jun 2009	10	6	2
Jul 2009	20	5	7
Aug 2009	22	6	5
Sep 2009	9	5	6
Oct 2009	30	10	10
Nov 2009	24	6	18
Dec 2009	23	1	7
Jan 2010	25	16	7
Feb 2010	18	6	7
Mar 2010	19	8	5
Apr 2010	17	9	8
May 2010	24	12	13
Jun 2010	29	8	12
Jul 2010	15	14	18
Aug 2010	23	22	8
Sep 2010	21	2	5
Oct 2010	22	20	10
Nov 2010	18	9	5
Dec 2010	11	8	3
Jan 2011	24	9	7
Feb 2011	20	11	7
Mar 2011	44	8	5
Apr 2011	17	10	5
May 2011	33	7	6
Jun 2011	20	8	3
Jul 2011	33	5	2
Aug 2011	25	7	9
Sep 2011	27	7	5
Oct 2011	32	6	12
Nov 2011	16	19	9
Dec 2011	39	33	21
Jan 2012	31	38	19
Feb 2012	26	33	10
Mar 2012	40	24	19
Apr 2012	24	33	16
May 2012	25	56	22
Jun 2012	27	27	16
Jul 2012	22	35	14
Aug 2012	22	30	26
Sep 2012	21	81	15
Oct 2012	33	38	17
Nov 2012	27	41	26
Dec 2012	31	27	18
Jan 2013	36	30	25
Feb 2013	22	40	13
Mar 2013	37	57	26
Apr 2013	30	46	29
May 2013	24	38	21
Jun 2013	31	32	17
Jul 2013	21	29	15
Aug 2013	25	29	14
Sep 2013	24	35	16
Oct 2013	34	60	27
Nov 2013	32	68	17
Dec 2013	27	40	14
Jan 2014	35	59	23
Feb 2014	24	57	30
Mar 2014	38	63	30
Apr 2014	51	100	33
May 2014	33	61	22
Jun 2014	28	50	12
Jul 2014	38	76	20
Aug 2014	16	41	20
Sep 2014	43	67	14
Oct 2014	47	57	26
Nov 2014	57	55	34
Dec 2014	46	122	22
Jan 2015	35	138	20
Feb 2015	94	69	14
Mar 2015	87	100	31
Apr 2015	49	68	14
May 2015	49	71	24
Jun 2015	55	46	18
Jul 2015	42	37	12
Aug 2015	60	32	17
Sep 2015	73	52	16
Oct 2015	30	23	15
Nov 2015	58	53	27
Dec 2015	58	56	13
Jan 2016	73	46	15
Feb 2016	84	31	16
Mar 2016	81	55	139
Apr 2016	73	54	33
May 2016	37	84	14
Jun 2016	55	129	15
Jul 2016	70	32	12
Aug 2016	69	43	16
Sep 2016	52	35	16
Oct 2016	73	45	20
Nov 2016	45	50	23
Dec 2016	64	51	16
Jan 2017	55	145	17
Feb 2017	34	238	30
Mar 2017	1	252	27
Apr 2017	1	210	21
May 2017	0	142	24
Jun 2017	25	158	21
Jul 2017	83	83	23
Aug 2017	126	126	29
Sep 2017	163	162	25
Oct 2017	144	145	31
Nov 2017	126	126	47
Dec 2017	125	125	30
Jan 2018	127	127	30
Feb 2018	100	99	29
Mar 2018	132	132	59
Apr 2018	141	143	43
May 2018	103	104	42
Jun 2018	124	124	51
Jul 2018	104	104	23
Aug 2018	134	134	25
Sep 2018	120	120	29
Oct 2018	181	182	41
Nov 2018	122	122	40
Dec 2018	95	95	21
Jan 2019	122	112	31
Feb 2019	119	97	28
Mar 2019	147	110	49
Apr 2019	136	118	49
May 2019	156	138	39
Jun 2019	126	115	48
Jul 2019	164	149	45
Aug 2019	105	93	21
Sep 2019	140	130	26
Oct 2019	157	140	51
Nov 2019	134	122	43
Dec 2019	129	123	20
Jan 2020	169	148	32
Feb 2020	161	141	39
Mar 2020	111	99	36
Apr 2020	135	104	53
May 2020	107	95	38
Jun 2020	153	136	35
Jul 2020	68	59	27
Aug 2020	92	80	44
Sep 2020	140	127	34
Oct 2020	122	99	44
Nov 2020	198	178	48
Dec 2020	125	111	33
Jan 2021	142	128	40
Feb 2021	227	211	166
Mar 2021	287	275	321
Apr 2021	202	192	362
May 2021	180	151	319
Jun 2021	110	100	190
Jul 2021	169	153	217
Aug 2021	139	131	281
Sep 2021	145	134	203
Oct 2021	161	152	285
Nov 2021	184	166	86
Dec 2021	237	228	54
Jan 2022	233	230	78
Feb 2022	230	234	47
Mar 2022	496	480	75
Apr 2022	234	211	64
May 2022	235	228	46
Jun 2022	146	131	42
Jul 2022	130	123	35
Aug 2022	144	140	38
Sep 2022	148	134	46
Oct 2022	200	189	45
Nov 2022	194	174	38
Dec 2022	215	199	49
Jan 2023	196	195	69
Feb 2023	184	160	51
Mar 2023	330	295	76
Apr 2023	124	117	65
May 2023	124	101	47
Jun 2023	129	109	36
Jul 2023	141	125	82
Aug 2023	152	128	44
Sep 2023	181	165	67
Oct 2023	265	244	60
Nov 2023	557	507	45
Dec 2023	1009	71	13
Jan 2024	355	20	10
Feb 2024	457	7	6
Mar 2024	405	16	9
Total	20166	20023	9030

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