Article Text

Download PDFPDF

The intestinal mucosa as a target and trigger for enteric reflexes
Free
  1. D Grundy
  1. Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield Sl0 2TN, UK
  1. Dr D Grundy. d.grundy{at}sheffield.ac.uk

Statistics from Altmetric.com

The gastrointestinal tract must balance the ostensibly conflicting needs of nutrient assimilation and protection against potentially harmful pathogens, enterotoxins, and antigens. Furthermore, it must provide a functional barrier for the latter but allow nutrients, electrolytes, and water to cross the mucosa readily in order to meet the eventual metabolic demands of the individual (fig 1). Apparent in these conflicting needs is the ability to sense luminal contents in order to establish, through reflex and endocrine mechanisms, the appropriate motor and secretory activity either to facilitate uptake or to dilute and rapidly expel contents through diarrhoea and/or emesis.

Figure 1

Conflicting mucosal functions.

Enteroendocrine cells may be secondary sense cells for sensory signal transduction. Their apical microvilli could detect the mechanical and chemical environment in the lumen, and in response to an appropriate stimulus would release mediators across the basolateral membrane. These mediators could then act as paracrine agents on neighbouring cells, including the terminals of afferent fibres situated below the mucosal epithelium or act in an endocrine fashion following diffusion into the systemic …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.