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Regression of gastric T cell lymphoma with eradication ofHelicobacter pylori

Abstract

Helicobacter pylori is thought to be important in the pathogenesis of chronic active gastritis, peptic ulceration, gastric adenocarcinoma, and gastric B cell lymphoma of mucosa associated lymphoid tissue. The mechanism of evolution from chronic gastritis to monoclonal B cell proliferation is not known but is thought to be dependent on antigen specific T cells toH pylori and its products. Here, we report a case of gastric T cell lymphoma associated with chronicH pylori gastritis which regressed with eradication of the organism. This is the first report of a gastric T cell lymphoma regressing with H pylorieradication, and suggests a causal link between primary gastric T cell lymphoma and this organism.

  • Helicobacter pylori
  • T cell lymphoma
  • Abbreviations used in this paper

    MALT
    mucosa associated lymphoid tissue
    PCR
    polymerase chain reaction
    TCR
    T cell receptor
    NK
    natural killer
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