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Long term follow up of interferon responder children with chronic hepatitis B
  1. N KOÇAK,
  2. I N SALTIK,
  3. H ÖZEN,
  4. F GÜRAKAN,
  5. A YÜCE
  1. Department of Pediatrics, Gastroenterology Unit
  2. Hacettepe University I˙hsan Doğramacı
  3. Children's Hospital, Ankara, Turkey
  1. Dr N Koçak, HacettepeI˙hsan Doğramacı Çocuk Hastanesi, Gastroenteroloji Ünitesi, 06100 Ankara, Turkey.haozen{at}hacettepe.edu.tr

https://doi.org/10.1136/gut.48.5.740

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    Editor,—We read Bortolotti et al's article ((2000) Gut 46:715–18; OpenUrlCrossRefPubMedWeb of Science) reporting the long term effect of interferon (IFN) alpha in children with chronic hepatitis B (HBV). Briefly, a total of 107 children with chronic HBV who received IFN alpha for three or six months in two clinical trials were followed for a mean period of 69 months. In the first trial 19 and 20 cases received IFN alpha at a dose of 3 and 7.5 MU/m2 three times a week for six months, respectively. In the second trial 34 cases received lymphoblastoid IFN at a dose of 5 MU/m2 for 12 weeks and 30 cases received IFN at the same dose but preceded by a four week course of prednisolone. Response to treatment was defined as loss of hepatitis B e antigen (HBeAg) within …

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