Article Text

Download PDFPDF

The African enigma: the parasite's perspective
  1. J G FOX
  1. Division of Comparative Medicine
  2. Massachusetts Institute of Technology
  3. 77 Massachusetts Ave
  4. Bldg. 16-825C, Cambridge, MA 02139, USA
  5. Division of Gastroenterology
  6. University of Massachusetts Medical Center
  7. Biotech 2, Suite 202, 373 Plantation St
  8. Worcester, MA 01605-2377, USA
  9. Mucosal Immunology Laboratory
  10. Massachusetts General Hospital East
  11. Building 149, 13th Street, Charlestown, MA 02129, USA
  1. JG Fox. jgfox{at}mit.edu
  1. T C WANG
  1. Division of Comparative Medicine
  2. Massachusetts Institute of Technology
  3. 77 Massachusetts Ave
  4. Bldg. 16-825C, Cambridge, MA 02139, USA
  5. Division of Gastroenterology
  6. University of Massachusetts Medical Center
  7. Biotech 2, Suite 202, 373 Plantation St
  8. Worcester, MA 01605-2377, USA
  9. Mucosal Immunology Laboratory
  10. Massachusetts General Hospital East
  11. Building 149, 13th Street, Charlestown, MA 02129, USA
  1. JG Fox. jgfox{at}mit.edu
  1. C NAGLER-ANDERSON
  1. Division of Comparative Medicine
  2. Massachusetts Institute of Technology
  3. 77 Massachusetts Ave
  4. Bldg. 16-825C, Cambridge, MA 02139, USA
  5. Division of Gastroenterology
  6. University of Massachusetts Medical Center
  7. Biotech 2, Suite 202, 373 Plantation St
  8. Worcester, MA 01605-2377, USA
  9. Mucosal Immunology Laboratory
  10. Massachusetts General Hospital East
  11. Building 149, 13th Street, Charlestown, MA 02129, USA
  1. JG Fox. jgfox{at}mit.edu

Statistics from Altmetric.com

Editor,—We would like to thank Professor MacDonald for his interest in our work, and for his recent comment on our paper (

). However, we must take issue with a number of his comments.

With respect to the clinical implications of our study,1 we have not advocated treatment ofHelicobacter pylori infected patients with intestinal parasites for the purpose of inducing a shift in the Th1/Th2 immune response, a possibility raised by Professor MacDonald. As Professor MacDonald is well aware, this approach has been suggested for a number of chronic diseases such as inflammatory bowel disease. However, in the case of chronic H pylori infection, antibiotic therapy has proved effective and in our opinion is a much safer and more palatable approach for most patients.

We appreciate Professor MacDonald's careful analysis of our histopathological results. However, we are confused regarding his comments of “negative points” that were not sufficiently emphasised. …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.