Association of the tumour necrosis factor α −308 but not the interleukin 10 −627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis

S A Mitchell; J Grove; A Spurkland; K M Boberg; K A Fleming; C P Day; E Schrumpf; R W Chapman; the European Study Group of Primary Sclerosing Cholangitis

doi:10.1136/gut.49.2.288

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Liver disease

Association of the tumour necrosis factor α −308 but not the interleukin 10 −627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis

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	Abstract	Full	Pdf
Jul 2001	37	79	35
Aug 2001	15	72	30
Sep 2001	22	50	19
Oct 2001	4	35	7
Nov 2001	7	21	5
Dec 2001	2	17	9
Jan 2002	0	25	19
Feb 2002	1	9	4
Mar 2002	3	13	4
Apr 2002	6	15	8
May 2002	2	16	8
Jun 2002	1	15	4
Jul 2002	2	11	4
Aug 2002	4	6	3
Sep 2002	1	13	4
Oct 2002	0	17	10
Nov 2002	1	10	8
Dec 2002	1	10	3
Jan 2003	2	5	5
Feb 2003	1	10	5
Mar 2003	3	10	13
Apr 2003	4	13	8
May 2003	5	4	4
Jun 2003	0	5	8
Jul 2003	9	8	2
Aug 2003	12	10	5
Sep 2003	8	12	4
Oct 2003	10	12	5
Nov 2003	9	22	15
Dec 2003	17	12	1
Jan 2004	11	19	7
Feb 2004	13	8	1
Mar 2004	15	12	4
Apr 2004	13	8	3
May 2004	30	33	6
Jun 2004	47	42	10
Jul 2004	45	61	12
Aug 2004	27	44	12
Sep 2004	25	33	7
Oct 2004	6	36	14
Nov 2004	5	20	13
Dec 2004	7	14	6
Jan 2005	9	21	6
Feb 2005	8	19	9
Mar 2005	10	22	11
Apr 2005	1	14	9
May 2005	5	14	3
Jun 2005	5	7	4
Jul 2005	3	19	5
Aug 2005	3	14	12
Sep 2005	9	17	15
Oct 2005	4	20	15
Nov 2005	12	23	12
Dec 2005	0	16	7
Jan 2006	5	15	11
Feb 2006	5	12	10
Mar 2006	1	29	17
Apr 2006	1	14	7
May 2006	1	10	5
Jun 2006	0	1	4
Jul 2006	1	12	7
Aug 2006	0	6	4
Sep 2006	0	16	10
Oct 2006	4	19	13
Nov 2006	3	14	14
Dec 2006	3	13	6
Jan 2007	3	9	6
Feb 2007	3	11	3
Mar 2007	2	26	21
Apr 2007	2	4	5
May 2007	6	9	8
Jun 2007	4	3	3
Jul 2007	3	4	2
Aug 2007	8	0	1
Sep 2007	4	7	3
Oct 2007	2	2	1
Nov 2007	7	4	5
Dec 2007	4	1	1
Jan 2008	3	2	2
Feb 2008	8	3	2
Mar 2008	28	3	3
Apr 2008	8	4	2
May 2008	11	1	1
Jun 2008	4	1	0
Jul 2008	26	0	0
Aug 2008	46	4	3
Sep 2008	39	2	1
Oct 2008	23	1	0
Nov 2008	15	2	1
Dec 2008	5	1	0
Jan 2009	6	2	3
Feb 2009	4	1	2
Mar 2009	17	4	5
Apr 2009	7	4	2
May 2009	1	2	1
Jun 2009	2	1	1
Jul 2009	6	0	0
Aug 2009	1	0	0
Sep 2009	10	1	2
Oct 2009	12	1	0
Nov 2009	13	0	0
Dec 2009	3	0	2
Jan 2010	8	2	4
Feb 2010	2	0	0
Mar 2010	7	0	0
Apr 2010	2	2	0
May 2010	8	2	2
Jun 2010	10	1	2
Jul 2010	0	3	7
Aug 2010	3	1	3
Sep 2010	1	2	2
Oct 2010	2	2	0
Nov 2010	2	1	0
Dec 2010	1	0	0
Jan 2011	2	2	1
Feb 2011	1	3	0
Mar 2011	3	0	0
Apr 2011	4	1	1
May 2011	6	1	1
Jun 2011	3	2	2
Jul 2011	4	0	0
Aug 2011	6	0	0
Sep 2011	8	0	0
Oct 2011	8	2	1
Nov 2011	6	2	1
Dec 2011	10	8	12
Jan 2012	3	3	4
Feb 2012	5	0	2
Mar 2012	6	6	6
Apr 2012	5	1	2
May 2012	11	5	5
Jun 2012	11	3	6
Jul 2012	17	5	8
Aug 2012	12	4	4
Sep 2012	8	2	6
Oct 2012	10	5	5
Nov 2012	12	3	6
Dec 2012	20	4	8
Jan 2013	8	2	2
Feb 2013	11	9	5
Mar 2013	7	6	1
Apr 2013	10	3	6
May 2013	4	3	3
Jun 2013	2	4	3
Jul 2013	6	4	0
Aug 2013	11	1	2
Sep 2013	9	2	0
Oct 2013	9	21	0
Nov 2013	7	1	3
Dec 2013	18	6	5
Jan 2014	6	2	1
Feb 2014	2	4	1
Mar 2014	9	7	5
Apr 2014	10	8	10
May 2014	9	6	8
Jun 2014	1	3	0
Jul 2014	13	13	2
Aug 2014	7	2	2
Sep 2014	5	5	3
Oct 2014	3	1	2
Nov 2014	20	2	4
Dec 2014	2	2	1
Jan 2015	3	1	2
Feb 2015	2	4	4
Mar 2015	7	4	1
Apr 2015	3	5	1
May 2015	6	1	0
Jun 2015	5	0	2
Jul 2015	3	1	0
Aug 2015	5	1	1
Sep 2015	12	3	5
Oct 2015	3	1	4
Nov 2015	6	2	2
Dec 2015	4	0	0
Jan 2016	2	12	4
Feb 2016	5	11	3
Mar 2016	2	1	5
Apr 2016	8	0	5
May 2016	15	1	10
Jun 2016	4	2	5
Jul 2016	10	2	3
Aug 2016	15	4	3
Sep 2016	15	5	4
Oct 2016	8	2	3
Nov 2016	15	2	2
Dec 2016	7	1	1
Jan 2017	13	2	8
Feb 2017	4	0	1
Mar 2017	2	5	1
Apr 2017	1	5	3
May 2017	0	5	2
Jun 2017	1	4	2
Jul 2017	7	7	1
Aug 2017	6	3	0
Sep 2017	7	7	1
Oct 2017	68	66	1
Nov 2017	9	7	1
Dec 2017	13	13	0
Jan 2018	8	6	0
Feb 2018	11	9	2
Mar 2018	11	9	0
Apr 2018	8	9	2
May 2018	12	13	0
Jun 2018	17	17	1
Jul 2018	19	19	3
Aug 2018	10	10	2
Sep 2018	14	14	2
Oct 2018	11	11	3
Nov 2018	13	13	2
Dec 2018	15	15	1
Jan 2019	5	5	1
Feb 2019	13	13	1
Mar 2019	16	15	5
Apr 2019	14	13	9
May 2019	11	11	4
Jun 2019	7	7	10
Jul 2019	7	7	7
Aug 2019	4	4	4
Sep 2019	6	7	3
Oct 2019	7	7	4
Nov 2019	6	6	0
Dec 2019	8	8	6
Jan 2020	3	3	5
Feb 2020	3	3	1
Mar 2020	6	6	4
Apr 2020	3	3	3
May 2020	1	1	2
Jun 2020	10	8	8
Jul 2020	13	11	5
Aug 2020	16	16	2
Sep 2020	13	13	3
Oct 2020	14	11	0
Nov 2020	16	16	3
Dec 2020	16	15	3
Jan 2021	13	13	5
Feb 2021	8	8	3
Mar 2021	5	5	2
Apr 2021	5	5	3
May 2021	6	6	6
Jun 2021	3	3	0
Jul 2021	7	7	6
Aug 2021	4	3	5
Sep 2021	11	11	5
Oct 2021	12	12	19
Nov 2021	12	8	20
Dec 2021	10	10	3
Jan 2022	12	13	2
Feb 2022	13	11	10
Mar 2022	12	10	4
Apr 2022	6	6	4
May 2022	22	20	14
Jun 2022	15	15	5
Jul 2022	12	12	1
Aug 2022	27	27	2
Sep 2022	22	20	11
Oct 2022	19	19	6
Nov 2022	8	7	1
Dec 2022	11	11	1
Jan 2023	21	19	5
Feb 2023	39	35	4
Mar 2023	1	1	10
Apr 2023	5	5	34
May 2023	4	4	6
Jun 2023	2	2	1
Jul 2023	5	5	5
Aug 2023	5	3	10
Sep 2023	4	4	15
Oct 2023	11	11	3
Nov 2023	43	41	1
Dec 2023	134	12	0
Jan 2024	26	4	3
Feb 2024	18	0	0
Mar 2024	153	2	2
Total	2697	2523	1271

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