Article Text

Download PDFPDF

Monocytes or T cells in Crohn's disease: does IL-16 allow both to play at that game?
  1. Department of General Internal Medicine
  2. Christian-Albrechts-University, Kiel, Germany
  1. Professor S Schreiber, Ist Department of Medicine, Christian-Albrechts-Universtität Kiel, Schittenhelmstr. 12, D-24105 Kiel, Germany. s.schreiber{at}

Statistics from

See article on page 795

Interleukin (IL)-16 was first described in 1982 under the name “lymphocyte chemoattractant factor”.1 Since its cloning in 1994,2 the complex structure and biological function of this cytokine has been extensively explored. In 1999, the IL-16 gene was localised to chromosome 15q26.33 but the role of genetic variants of this gene have yet to be explored in human disease.

IL-16 can be produced by a variety of inflammatory cells, including mast cells, eosinophils, mononuclear phagocytes, and CD4+ and CD8+ T cells.4 IL-16 is expressed as an 80 kDa precursor molecule,5 which is processed to active IL-16 by caspase 3.6

Most interestingly, the main receptor for IL-16 appears to be the CD4 molecule (which identifies T helper cells but is also present on monocytes and other phagocytes). It is assumed that interaction with the CD4 molecule is the …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles