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Why measure thiopurine methyltransferase activity? Direct administration of 6-thioguanine might be the alternative for 6-mercaptopurine or azathioprine
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- Published on: 9 January 2022
- Published on: 9 January 2022Further research is needed on the role of TPMT activity in 6 thioguanine prescribingShow More
Dear Editor
In their letter de Jong et al (Gut 2001;49:874-875) state that in IBD the efficacy and myelotoxicity of 6-mercaptopurine (6-MP) and azathioprine (AZA) are related to the 6-thioguanine (6-TG) levels achieved. It is thought that the 6-thioguanine nucleotides (6-TGN) are the predominantly active metabolite of AZA/6-MP and that efficacy and myelotoxicity seem to be related to 6-thioguanine metabolite level...
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