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Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells
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  • Published on:
    Re: Mechanism of stimulation of pepsinogen release by H. pylori

    Dear Editor

    We are very grateful for the interest shown and comments made by Dr Beales regarding our study [1]. We agree with him that it would have been interesting to study the effects of H. pylori infection on the responses to other physiological agonists. Unfortunately, the number of cells obtained from the human stomach with endoscopic biopsies is much lower than that obtained from the entire stomach in expe...

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    Conflict of Interest:
    None declared.
  • Published on:
    Mechanism of stimulation of pepsinogen release by H. pylori

    Dear Editor

    The paper by Lorente et al (Gut 2000; 50: 13-18) demonstrates that H. pylori stimulates pepsinogen release from human chief cells in vitro. The precision of the results obtained from cells from 70 different subjects is to be complimented but several aspects of presentation and interpretation require further discussion.

    The authors report no differences in basal or H. pylori-stimulated pepsinogen...

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    Conflict of Interest:
    None declared.