Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon γ

H Tilg; C van Montfrans; A van den Ende; A Kaser; S J H van Deventer; S Schreiber; M Gregor; O Ludwiczek; P Rutgeerts; C Gasche; J C Koningsberger; L Abreu; I Kuhn; M Cohard; A LeBeaut; P Grint; G Weiss

doi:10.1136/gut.50.2.191

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Inflammation and inflammatory bowel disease

Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon γ

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	Abstract	Full	Pdf
Jan 2002	145	669	269
Feb 2002	105	425	165
Mar 2002	38	80	35
Apr 2002	29	62	38
May 2002	13	38	18
Jun 2002	6	29	13
Jul 2002	11	36	21
Aug 2002	5	31	15
Sep 2002	7	37	20
Oct 2002	14	36	12
Nov 2002	6	29	16
Dec 2002	36	31	25
Jan 2003	14	25	14
Feb 2003	10	22	8
Mar 2003	10	15	7
Apr 2003	14	29	25
May 2003	15	20	9
Jun 2003	12	26	4
Jul 2003	16	32	15
Aug 2003	25	26	14
Sep 2003	25	16	4
Oct 2003	18	21	12
Nov 2003	27	19	11
Dec 2003	26	15	13
Jan 2004	27	16	3
Feb 2004	33	20	9
Mar 2004	26	18	7
Apr 2004	35	11	12
May 2004	48	31	9
Jun 2004	44	49	15
Jul 2004	55	60	8
Aug 2004	31	60	10
Sep 2004	25	45	8
Oct 2004	24	35	10
Nov 2004	11	32	19
Dec 2004	17	26	10
Jan 2005	25	74	20
Feb 2005	11	37	16
Mar 2005	24	27	16
Apr 2005	7	11	14
May 2005	5	10	15
Jun 2005	19	16	16
Jul 2005	18	13	7
Aug 2005	10	18	12
Sep 2005	14	21	11
Oct 2005	14	30	9
Nov 2005	16	28	5
Dec 2005	6	22	4
Jan 2006	14	23	9
Feb 2006	3	27	12
Mar 2006	12	24	14
Apr 2006	5	15	8
May 2006	5	9	5
Jun 2006	14	21	13
Jul 2006	8	9	5
Aug 2006	6	11	6
Sep 2006	8	10	8
Oct 2006	15	22	15
Nov 2006	17	16	12
Dec 2006	18	11	11
Jan 2007	9	9	10
Feb 2007	13	11	7
Mar 2007	34	24	24
Apr 2007	16	6	8
May 2007	15	5	1
Jun 2007	10	6	9
Jul 2007	8	4	7
Aug 2007	10	1	2
Sep 2007	10	8	8
Oct 2007	16	1	5
Nov 2007	29	8	12
Dec 2007	12	4	3
Jan 2008	18	6	4
Feb 2008	20	9	11
Mar 2008	35	7	4
Apr 2008	20	9	11
May 2008	30	4	3
Jun 2008	10	2	1
Jul 2008	34	3	2
Aug 2008	66	6	2
Sep 2008	84	3	3
Oct 2008	39	6	6
Nov 2008	36	2	7
Dec 2008	9	2	0
Jan 2009	11	3	6
Feb 2009	13	3	3
Mar 2009	49	5	7
Apr 2009	31	2	4
May 2009	34	2	6
Jun 2009	14	0	0
Jul 2009	13	2	4
Aug 2009	5	1	1
Sep 2009	19	1	2
Oct 2009	22	4	4
Nov 2009	31	2	2
Dec 2009	6	0	0
Jan 2010	9	9	6
Feb 2010	24	0	3
Mar 2010	9	1	1
Apr 2010	16	5	0
May 2010	9	1	1
Jun 2010	6	9	13
Jul 2010	9	7	6
Aug 2010	20	3	3
Sep 2010	4	1	4
Oct 2010	8	7	1
Nov 2010	11	3	2
Dec 2010	4	3	1
Jan 2011	10	8	2
Feb 2011	8	7	4
Mar 2011	14	9	9
Apr 2011	8	1	0
May 2011	13	3	4
Jun 2011	12	3	2
Jul 2011	6	0	4
Aug 2011	14	1	2
Sep 2011	17	3	3
Oct 2011	20	3	1
Nov 2011	40	9	6
Dec 2011	22	12	7
Jan 2012	13	5	5
Feb 2012	10	2	2
Mar 2012	22	4	3
Apr 2012	10	7	6
May 2012	16	15	6
Jun 2012	22	21	12
Jul 2012	22	12	10
Aug 2012	14	11	13
Sep 2012	23	12	20
Oct 2012	23	16	12
Nov 2012	15	11	10
Dec 2012	29	13	4
Jan 2013	24	16	13
Feb 2013	23	35	11
Mar 2013	36	13	10
Apr 2013	28	9	9
May 2013	18	13	11
Jun 2013	13	11	5
Jul 2013	8	7	6
Aug 2013	10	14	10
Sep 2013	13	7	3
Oct 2013	12	12	4
Nov 2013	15	12	9
Dec 2013	27	6	10
Jan 2014	14	8	4
Feb 2014	9	11	5
Mar 2014	19	15	11
Apr 2014	13	21	8
May 2014	12	17	5
Jun 2014	11	10	6
Jul 2014	29	19	6
Aug 2014	9	12	1
Sep 2014	8	20	13
Oct 2014	13	11	4
Nov 2014	19	10	8
Dec 2014	7	8	5
Jan 2015	12	16	6
Feb 2015	9	22	14
Mar 2015	10	21	10
Apr 2015	10	10	6
May 2015	20	19	5
Jun 2015	15	17	7
Jul 2015	38	12	7
Aug 2015	9	11	2
Sep 2015	21	20	5
Oct 2015	4	12	3
Nov 2015	15	5	3
Dec 2015	20	17	6
Jan 2016	17	11	6
Feb 2016	20	13	6
Mar 2016	10	16	12
Apr 2016	20	9	13
May 2016	10	10	7
Jun 2016	8	10	2
Jul 2016	17	21	9
Aug 2016	10	13	6
Sep 2016	35	14	71
Oct 2016	17	16	9
Nov 2016	23	21	5
Dec 2016	22	25	4
Jan 2017	23	17	10
Feb 2017	0	18	7
Mar 2017	0	27	8
Apr 2017	1	33	6
May 2017	0	25	7
Jun 2017	4	19	4
Jul 2017	31	31	10
Aug 2017	41	41	8
Sep 2017	41	41	5
Oct 2017	31	31	5
Nov 2017	40	40	6
Dec 2017	33	33	8
Jan 2018	41	41	11
Feb 2018	42	40	10
Mar 2018	186	184	6
Apr 2018	51	51	4
May 2018	62	63	8
Jun 2018	46	46	4
Jul 2018	54	54	6
Aug 2018	79	79	4
Sep 2018	64	64	7
Oct 2018	101	101	11
Nov 2018	116	116	17
Dec 2018	133	133	6
Jan 2019	109	105	9
Feb 2019	95	87	10
Mar 2019	86	72	19
Apr 2019	57	52	26
May 2019	49	35	23
Jun 2019	38	33	16
Jul 2019	51	43	24
Aug 2019	54	48	16
Sep 2019	36	36	18
Oct 2019	47	46	12
Nov 2019	51	46	20
Dec 2019	64	44	10
Jan 2020	43	40	7
Feb 2020	45	43	15
Mar 2020	59	57	13
Apr 2020	64	63	22
May 2020	45	40	26
Jun 2020	49	43	20
Jul 2020	36	35	10
Aug 2020	38	37	9
Sep 2020	42	40	42
Oct 2020	61	57	20
Nov 2020	46	43	21
Dec 2020	43	39	19
Jan 2021	35	34	16
Feb 2021	43	39	12
Mar 2021	117	109	40
Apr 2021	51	48	15
May 2021	59	53	25
Jun 2021	37	30	7
Jul 2021	47	47	17
Aug 2021	33	29	31
Sep 2021	37	35	17
Oct 2021	75	66	40
Nov 2021	44	41	30
Dec 2021	37	40	20
Jan 2022	54	50	11
Feb 2022	52	50	20
Mar 2022	79	73	33
Apr 2022	78	72	20
May 2022	58	51	26
Jun 2022	64	56	17
Jul 2022	69	55	23
Aug 2022	55	54	19
Sep 2022	60	54	19
Oct 2022	52	53	24
Nov 2022	51	51	23
Dec 2022	45	42	11
Jan 2023	87	82	16
Feb 2023	107	109	26
Mar 2023	87	80	26
Apr 2023	40	37	21
May 2023	51	44	17
Jun 2023	50	46	10
Jul 2023	59	58	15
Aug 2023	33	30	14
Sep 2023	58	63	13
Oct 2023	60	61	15
Nov 2023	75	51	12
Dec 2023	138	10	4
Jan 2024	125	9	6
Feb 2024	111	3	4
Mar 2024	357	6	2
Total	8740	8196	3266

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