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Gut adaptation and the glucagon-like peptides
  1. D J Drucker
  1. Correspondence to:
    D J Drucker, The Banting and Best Diabetes Centre, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada M5G 2C4


The glucagon-like peptides GLP-1 and GLP-2 are synthesised and then released from enteroendocrine cells in the small and large intestine. GLP-1 promotes efficient nutrient assimilation while GLP-2 regulates energy absorption via effects on nutrient intake, gastric acid secretion and gastric emptying, nutrient absorption, and mucosal permeability. Preliminary human studies indicate that GLP-2 may enhance energy absorption and reduce fluid loss in subjects with short bowel syndrome suggesting that GLP-2 functions as a key regulator of mucosal integrity, permeability, and nutrient absorption. Hence GLP-2 may be therapeutically useful in diseases characterised by injury or dysfunction of the gastrointestinal epithelium.

  • short bowel
  • intestine
  • gut adaptation
  • glucagon-like peptides
  • enteroendocrine
  • appetite
  • mucositis
  • nutrition
  • GLP-1, GLP-2, glucagon-like peptides 1 and 2
  • GLI, glucagon-like immunoreactivity
  • PGDP, proglucagon derived peptide
  • IP-1, IP-2, intervening peptides 1 and-2
  • DP IV, dipeptidyl peptidase IV
  • PKA, protein kinase A
  • GLP-2R, GLP-2 receptor

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