Article Text

Download PDFPDF

Gut adaptation and the glucagon-like peptides
  1. D J Drucker
  1. Correspondence to:
    D J Drucker, The Banting and Best Diabetes Centre, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada M5G 2C4
    d.drucker{at}utoronto.ca

Abstract

The glucagon-like peptides GLP-1 and GLP-2 are synthesised and then released from enteroendocrine cells in the small and large intestine. GLP-1 promotes efficient nutrient assimilation while GLP-2 regulates energy absorption via effects on nutrient intake, gastric acid secretion and gastric emptying, nutrient absorption, and mucosal permeability. Preliminary human studies indicate that GLP-2 may enhance energy absorption and reduce fluid loss in subjects with short bowel syndrome suggesting that GLP-2 functions as a key regulator of mucosal integrity, permeability, and nutrient absorption. Hence GLP-2 may be therapeutically useful in diseases characterised by injury or dysfunction of the gastrointestinal epithelium.

  • short bowel
  • intestine
  • gut adaptation
  • glucagon-like peptides
  • enteroendocrine
  • appetite
  • mucositis
  • nutrition
  • GLP-1, GLP-2, glucagon-like peptides 1 and 2
  • GLI, glucagon-like immunoreactivity
  • PGDP, proglucagon derived peptide
  • IP-1, IP-2, intervening peptides 1 and-2
  • DP IV, dipeptidyl peptidase IV
  • PKA, protein kinase A
  • GLP-2R, GLP-2 receptor
View Full Text

Statistics from Altmetric.com

Footnotes

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.