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Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in rats
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  • Published on:
    Authors' reply to Pellegrini et al
    • Robin C Spiller, Professor of Gastroenterology
    • Other Contributors:
      • Paul Sherwood

    We thank Dr Pellegrini et al. for their interest [1] in our article.[2]

    As they correctly point out the very effective inhibition of acid secretion may interfere with acid trapping and thus decrease antibiotic transfer into the gastric juice. However, the final antibiotic concentration in gastric juice depends on both the rate of secretion and the rate of degradation. Although metronidazole and amoxycillin ar...

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    Conflict of Interest:
    None declared.
  • Published on:
    Influence of antisecretory drugs on Helicobacter pylori eradication rates
    • Michele Pellegrini, Consultant Gastroenterologist
    • Other Contributors:
      • Renato Urso, Giorgio Giorgi, Daniela Cerretani. “G. Segre” Department of Pharmacology, University of Siena, Italy

    Dear Editor

    We read with great interest the article by Sherwood et al.[1]

    In their study the authors evaluated the role of acid secretion and gastric luminal pH on the gastric transfer rate of amoxicillin, clarithromycin and metronidazole, showing that metronidazole and clarithromycin but not amoxicillin transfers were increased by acid secretion. The gastric acid suppression, induced by the use...

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    Conflict of Interest:
    None declared.