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Gastric hyperalgesia and changes in voltage gated sodium channel function in the rat
  1. G F Gebhart1,
  2. K Bielefeldt2,
  3. N Ozaki1
  1. 1Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa 52242-1109, USA
  2. 2Department of Internal Medicine (Gastroenterology), College of Medicine, University of Iowa, Iowa City, Iowa 52242-1109, USA
  1. Correspondence to:
    Dr G F Gebhart, Department of Pharmacology, University of Iowa, College of Medicine, 2-471 Bowen Science Building, Iowa City, IA 52242-1109, USA;
    gf-gebhart{at}uiowa.edu

Abstract

Potential peripheral mechanisms that might contribute to the development of visceral hypersensitivity and ultimately to the altered sensations that characterise functional gastrointestinal disorders were examined by developing experimental models of gastric hyperalgesia. A direct link between alteration in behaviour and potential mechanisms of increased excitability of the gastric afferent innervation was found.

  • sensitisation
  • excitability
  • hyperalgesia
  • sodium current
  • tetrodotoxin
  • CNS, central nervous system
  • HAc, acetic acid
  • IBS, irritable bowel syndrome
  • NGF, nerve growth factor
  • TTX, tetrodotoxin

https://doi.org/10.1136/gut.51.suppl_1.i15

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