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Neuroanatomy of visceral nociception: vagal and splanchnic afferent
  1. D Grundy
  1. Correspondence to:
    Dr D Grundy, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK;


Afferent fibres convey sensory information from the upper gastrointestinal tract to the central nervous system but the nature of this information is different for vagal and spinal pathways. Vagal afferents convey predominantly physiological information while spinal afferents are able to encode noxious events. Because of the different response profiles following activation of these pathways, it is likely that vagal and splanchnic afferents play different roles in mediating sensation.

  • vagal afferents
  • spinal afferents
  • mechanosensitivity
  • cholecystokinin
  • CCK, cholecystokinin
  • CGRP, calcitonin gene related peptide
  • CNS, central nervous system
  • EC, enteroendocrine cells
  • IGLE, intraganglionic lamina endings

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