You are here

Article Text

Article menu
Download PDFPDF
Papers
Prevertebral ganglia and intestinofugal afferent neurones
  1. J H Szurszewski,
  2. L G Ermilov,
  3. S M Miller
  1. Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, 55905 USA
  1. Correspondence to:
    Dr J H Szurszewski, Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA;
    gijoe{at}mayo.edu

Abstract

Intestinofugal afferent neurones (IFANs) are a unique subset of myenteric ganglion neurones that regulate normal gastrointestinal function. The IFANs relaying mechanosensory information to sympathetic neurones of the prevertebral ganglion (PVG) function as volume detectors. It is possible that mechanosensory information arriving in the PVG via axon collaterals of visceral spinal afferent nerves can be modulated entirely within the PVG itself.

  • prevertebral ganglia
  • sympathetic neurones
  • intestinal afferent nerves
  • mechanosensitivity
  • CGRP, calcitonin gene related peptide
  • F-EPSP, fast excitatory postsynaptic potential
  • GABA, gamma aminobutyric acid
  • IFAN, intestinofugal afferent neurone
  • IMA, intramuscular array
  • IMG, inferior mesenteric ganglion
  • IPAN, intrinsic primary afferent neurone
  • PVG, prevertebral ganglion
  • S-EPSP, slow excitatory postsynaptic potential
  • SMG, superior mesenteric ganglion
  • SP, substance P
  • VIP, vasoactive intestinal peptide

https://doi.org/10.1136/gut.51.suppl_1.i6

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text