Article Text

Download PDFPDF
Pathophysiology of functional dyspepsia
  1. M Thumshirn
  1. Correspondence to:
    Dr M Thumshirn, Department of Gastroenterology, University Hospital Zurich, Raemistrasse 100, CH- 8091 Zürich, Switzerland;


Functional dyspepsia is a symptom complex characterised by postprandial upper abdominal discomfort or pain, early satiety, nausea, vomiting, abdominal distension, bloating, and anorexia in the absence of organic disease. Gastrointestinal motor abnormalities, altered visceral sensation, and psychosocial factors have all been identified as major pathophysiological mechanisms. This perspective has now replaced the earlier view that the condition was the result of a sole motor or sensory disorder of the stomach. Future therapeutic strategies should be aimed at reducing nociception as well as enhancing the accommodation response.

  • functional dyspepsia
  • Helicobacter pylori
  • gastric accommodation
  • hypomotility
  • IBS, irritable bowel syndrome

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.