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Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets
  1. D W Hommes1,
  2. M P Peppelenbosch2,
  3. S J H van Deventer1
  1. 1Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, the Netherlands
  2. 2Department of Experimental Internal Medicine, Academic Medical Centre, Amsterdam, the Netherlands
  1. Dr DW Hommes, Department of Gastroenterology and Hepatology, Academic Medical Centre, C2-116, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands;


Over the last decade important advances have been made in our understanding of the molecular events underlying cellular responses to extracellular signals. Increased understanding of signal transduction mechanisms and gene regulation involved in immune responses has created opportunities for the discovery of novel therapeutic compounds useful in treating inflammatory disorders. One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses. Here, our current understanding of the MAP kinase pathway is reviewed, as well as recent advances in the design of novel agents that are able to modulate the activity of these signalling cascades.

  • mitogen activated protein kinase
  • MAP kinase
  • anti-inflammatory
  • signal transduction
  • AP-1, activating protein 1
  • ATF-2, activating transcription factor 2
  • ERK, extracellular signal regulated kinase
  • IFN, interferon
  • IL, interleukin
  • JAK, Janus kinase
  • JNK, c-Jun NH2 terminal kinase
  • LPS, lipopolysaccharide
  • MAP, mitogen activated protein
  • MAPK, MAP kinase
  • MAPKAP, MAP kinase activated protein kinase
  • MAPKK, MAP kinase kinase
  • MAPKKK, MAP kinase kinase kinase
  • MEF, myocyte enhance factor
  • MEK, MAP/ERK kinase
  • MKK, MAP kinase kinase
  • NF, nuclear factor
  • STAT, signal transducers and activators of transcription
  • TGF, transforming growth factor
  • TNF, tumour necrosis factor

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