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Commentary
HLA-DQ8 as an Ir gene in coeliac disease

Abstract

DQ8 restricted gliadin peptide is immunogenic in the intestinal mucosa of HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs, and strongly suggests that DQ2 and DQ8 act as immune response (Ir) genes in this disease

  • coeliac disease
  • gliadin peptides
  • HLA restriction
  • organ culture
  • mucosal immunity
  • Ir genes coeliac

https://doi.org/10.1136/gut.52.1.7

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