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Clinical @lert
Hepatic and extrahepatic malignancies and primary sclerosing cholangitis
  1. E Schrumpf,
  2. K M Boberg
  1. Medical Department A, Rikshospitalet, Oslo, Norway
  1. Correspondence to:
    E Schrumpf, Medical Department A, Rikshospitalet, N-0027 Oslo, Norway;
    erik.schrumpf{at}rikshospitalet.no

https://doi.org/10.1136/gut.52.2.165

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    There is an increased risk of pancreatic carcinoma in patients with primary sclerosing cholangitis

    The paper of Bergquist and colleagues1 is important for several reasons. In addition to confirming the increased risk of cholangiocarcinoma/hepatobiliary carcinoma in primary sclerosing cholangitis (PSC), they provide data on the size and nature of this risk. But more importantly, for the first time they demonstrate an increased risk of pancreatic cancer in addition to the well established risk of colonic malignancies in these patients. Thereby they demonstrate that PSC is a premalignant condition predisposing to several gastrointestinal cancers.

    PSC patients are undoubtedly at an increased risk of developing cholangiocarcionoma. The size of this risk is however not universally agreed upon.2 The present finding of 13% of hepatobiliary malignancies is based on the largest cohort of patients examined so far: as two thirds of all Swedish PSC patients were included, it is also probably the least selected series of patients. The high …

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