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Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies
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  • Published on:
    Author's reply
    • Laurent Castéra, M.D.
    • Other Contributors:
      • Jean-Michel Pawlotsky, Daniel Dhumeaux

    Dear Editor

    We thank Ratziu et al. for their interest in our work.[1]

    To grade steatosis, we used the Metavir scoring system, shown by their group to be accurate and reproducible.[2,3] Worsening was characterised by an increase in the amount of lipids in hepatocytes, as defined in this grading system. As emphasised in our paper, our main finding was that worsening of steatosis was the only independent...

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    Conflict of Interest:
    None declared.
  • Published on:
    Worsening of steatosis and fibrosis progression in hepatitis C.
    • Vlad D Ratziu, M.D.
    • Other Contributors:
      • Mihaela Saboury, Thierry Poynard

    Dear Editor

    We read with great interest the article by Laurent Castera and colleagues [1] and acknowledge the finding that worsening of steatosis in chronic hepatitis C, is associated with fibrosis progression. However, in our view the are no data supporting a casual role for this statistical association or any specific relation of this finding to chronic hepatitis C.

    First, the authors provide no expla...

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    Conflict of Interest:
    None declared.