Article Text

Download PDFPDF

Diagnosing small bowel Crohn’s disease with wireless capsule endoscopy
  1. Z Fireman1,
  2. E Mahajna1,
  3. E Broide2,
  4. M Shapiro2,
  5. L Fich1,
  6. A Sternberg1,
  7. Y Kopelman1,
  8. E Scapa2
  1. 1Department of Gastroenterology, Hillel-Yaffe Medical Center, Hadera, Israel
  2. 2Department of Gastroenterology, Asaf-Harofe Medical Center, Zrifin, Israel
  1. Correspondence to:
    Dr Z Fireman, Gastroenterology Department, Hillel Yaffe Medical Center, PO Box 169, Hadera 38100, Israel;


Background: The small bowel is the most commonly affected site of Crohn’s disease (CD) although it may involve any part of the gastrointestinal tract. The current methodologies for examining the small bowel are x ray and endoscopy.

Aims: To evaluate, for the first time, the effectiveness of wireless capsule endoscopy in patients with suspected CD of the small bowel undetected by conventional modalities, and to determine the diagnostic yield of the M2A Given Capsule.

Patients: Seventeen patients (eight males, mean age 40 (15) years) with suspected CD fulfilled study entry criteria: nine had iron deficiency anaemia (mean haemoglobin 10.5 (SD 1.8) g%), eight had abdominal pain, seven had diarrhoea, and three had weight loss. Small bowel x ray and upper and lower gastrointestinal endoscopic findings were normal. Mean duration of symptoms before diagnosis was 6.3 (SD 2.2) years.

Methods: Each subject swallowed an M2A Given Capsule containing a miniature video camera, batteries, a transmitter, and an antenna. Recording time was approximately eight hours. The capsule was excreted naturally in the patient’s bowel movement, and the data it contained were retrieved and interpreted the next day.

Results: Of the 17 study participants, 12 (70.6%, six males, mean age 34.5 (12) years) were diagnosed as having CD of the small bowel according to the findings of the M2A Given Capsule.

Conclusions: Wireless capsule endoscopy diagnosed CD of the small bowel (diagnostic yield of 71%). It was demonstrated as being an effective modality for diagnosing patients with suspected CD undetected by conventional diagnostic methodologies.

  • CD, Crohn’s disease
  • CT, computerised tomography
  • ESR, erythrocyte sedimentation rate
  • OGD, oesophagogastroduodenoscopy
View Full Text

Statistics from


  • Drs Fireman and Scapa are members of the medical advisory board of Given Imaging.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.